Probiotics cause harmful effects when gut barrier becomes weak. The popularity of probiotics is growing at rapid pace and scientists, therefore, turning their attention to these particles. Now researchers show that their effect may be different for everyone.

However, grocery stores across the United States sell different products that include probiotics, offering the promise for healthy gut microbiome.

Research on the probiotics’ potential health benefits is still incomplete and not completely positive as their popularity is growing rapidly.

Now, engineers at the University of Texas conducted a new research at the Cockrell School of Engineering in Austin. For the study, they used forefront, organ-on-a-chip technology. Their work now appears in the Proceedings of the National Academy of Sciences.

During their study, the researchers found that so-called good bacteria may be beneficial some people but can create a negative impact on others health. They believe that good bacteria’s impact depends on the intestinal epithelium’s integrity.

“Once the gut barrier has been damaged, probiotics can be harmful just like any other bacteria that escape into the human body through a damaged intestinal barrier,” explains Researcher Woojung Shin.

Probiotics are positive only when the gut barrier is healthy. They can cause harmful effects if the gut barrier becomes weak.

Shin, a biomedical engineer who worked with study lead Hyun Jung Kim says “Essentially, ‘good fences make good neighbors.'”

Shin and colleagues would extend these findings in the future to build more customized intestinal disease models. He is interested to look for how bacteria affect inflammation, the spreading procedure of cancer and anticancer drugs’ performance.


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